Vision and Tommy join forces to track down Butcherbird and put an end to her murder spree. However, lingering trust issues between father and son threaten to create a worst-case scenario for the synthezoid.

Tommy and Vision remain on the run from Paladin, but their escape also gives them an opportunity to grow closer as father and son. Elsewhere, the AI avatars inside Vision’s mind scramble to repair the damage caused by the adamantium bullets. Unfortunately, their efforts may not be enough to keep Vision safe, as another threat begins closing in.

Vision and the AI personalities sharing his mind race to uncover how Tommy escaped the Hex. At the same time, Paladin sets a trap designed to capture Vision and deliver him to his mysterious employer. As the two storylines collide, one of Vision’s digital companions makes a heartbreaking decision that could change everything.

Following the events of WandaVision, Vision embarks on a journey to better understand what it means to be human. He finds companionship among the artificial intelligences living within his mind, but his quiet existence is disrupted when a bounty hunter comes after him. The pursuit leads to an unexpected discovery: one of the children created during Wanda's Hex may still be alive.

Gambit is back, but he isn't returning alone. He brings his former friends from his time before the X-Men along as he continues carrying out Apocalypse's plans. Meanwhile, X-Force joins forces with X-Corp in an attempt to restore the Gambit they once knew. However, Cable isn't entirely honest about why he's involved. 

As tensions continue to boil over between humans and mutants, a group of separatist mutants claim to be continuing the work of Magneto. They abduct the leader of an anti-mutant group who also happens to be the half-brother of Nightcrawler. It leads to a trial, a fight and an uneasy alliance between X-Corp and X-Factor.

Professor Xavier struggles to cope with Magneto's death, but his attempt to process that grief through the Danger Room creates an entirely new threat. At the same time, a former student serving with X-Factor returns to Xavier's School just as the X-Men face one of their most personal challenges yet.

Wolverine gathers the former Team X members for an attack on the lab where they were previously the subjects of experiments. However, he’s being less than truthful about his motivations for this mission leading to massive issues among the team.

Following Rama-Tut's devastating attack that claims Baal's life, Professor X and Magneto remain determined to prevent En Sabah Nur from becoming Apocalypse. Their mission, however, begins to unravel as their opposing philosophies, and the secrets each keeps from the other, push history closer to the very future they hoped to erase.

The X-Men team in the past has found the vessel who will become Apocalypse, En Sabah Nur. Magneto is trying to ensure the first mutant never becomes the greatest villain the X-Men will ever face. However, En Sabah Nur is trying to lead an uprising against a pharaoh who seems to be using futuristic, and almost alien, technology.

Back in the series' present-day timeline of 1997, the world has changed dramatically with the X-Men scattered across different eras. In their absence, two new mutant teams have emerged to defend humanity, however they take very different approaches. Cable assembles X-Force, an independent strike team, while the U.S. government introduces X-Factor, a state-backed group tasked with policing mutant activity.

Apocalypse's latest scheme has scattered the X-Men across three different points in time, forcing the team to fight on multiple fronts. While some mutants remain in 1997, others find themselves stranded in the distant past and far future. To stop Apocalypse before his plans reshape history, the heroes must reunite across time itself.